منابع مشابه
Genetics of Endometrial Cancers
Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological and clinical types. The most frequently altered gene in estrogen-dependent endometrioid endometrial carcinoma tumors is PTEN. Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent ...
متن کاملConcomitant endometrial and pancreatic cancers.
65-year-old woman presented with a 2-month history of postmenopausal bleeding. Her past medical history was significant for hypertension, type 2 diabetes, and a remote history of pulmonary embolism, and her surgical history was significant for a thyroidectomy for benign disease and a hip replacement. On physical examination, she was found to have a mass protruding through the cervix. Biopsy rev...
متن کاملOther Gynecologic Cancers: endometrial, ovarian, vulvar and vaginal cancers
HEALTH ISSUE: In Canada, cancers of the endometrium, ovaries, vulva, vagina, placenta and adnexa account for 11% of all malignant neoplasms in women and 81% of all genital cancers. Although the incidence and mortality from vulvar and vaginal cancers are very low, endometrium and ovarian cancer are important public health problems. KEY FINDINGS: In Canada, there has been no appreciable improveme...
متن کاملPTEN/MMAC1 mutations in endometrial cancers.
Endometrial carcinomas represent the most common gynecological cancer in the United States, yet the molecular genetic events that underlie the development of these tumors remain obscure. Chromosome 10 is implicated in the pathogenesis of endometrial carcinoma based on loss of heterozygosity (LOH), comparative genomic hybridization, and cytogenetics. Recently, a potential tumor suppressor gene, ...
متن کاملObesity-associated endometrial and cervical cancers.
Epidemiological studies have indicated that obesity (body mass index-BMI>30) and overweight (BMI>25) directly associated with risk of many cancers. The association of obesity with cancer risks may be explained by the alterations in the metabolism of endogenous hormones, production of specific proteins and cytokines, adipose related inflammatory reactions, and genetic factors. This review aims t...
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ژورنال
عنوان ژورنال: Obstetrics and Gynecology International
سال: 2010
ISSN: 1687-9589,1687-9597
DOI: 10.1155/2010/984013